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Is Keto Good For Inflammation

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Does A Ketogenic Diet Cause Inflammation

High Fat Diets vs. Inflammation- Keto Pain
  • Does a Ketogenic Diet Cause Inflammation?

In 2006, The American Journal of Clinical Nutrition released a study headed up by Dr Carol Johnston that seemed to show that the Ketogenic diet increased the amount of inflammation in the bodies of their test subjects. Since then, every once in a while someone will cite this report as proof that the Ketogenic diet causes inflammation. Lets take a look at this study and see what it says.

Is The Keto Diet Anti

The keto diet is sometimes seen as a healthy alternative to a low-carb diet. In the long term, it has been shown to have an anti-inflammatory effect.

The keto diet is often viewed as a healthy option for those who want to lose weight and lead a healthier lifestyle. Yet, many people are not aware that it also has an anti-inflammatory effect after long-term treatments.

Lets find out if the keto diet is inflammatory or not.

Suppresses Exercise Of Inflammatory Genes

Current analysis on the anti-inflammatory results of a keto weight loss plan discovered that ketogenic diets change off inflammatory genes.

The researchers discovered keto weight loss plan prompts a protein known as CtBP, which suppresses inflammatory genes.

This anti-inflammatory impact of ketosis explains the advantages of keto diets for some types of epilepsy and different neurological diseases.

A keto weight loss plan may also assist to scale back mind irritation that happens after a stroke.

Findings from animal checks point out that keto diets may even be helpful for sufferers affected by mind accidents, bettering therapy outcomes and probably extending lifespans.

This anti-inflammatory impact of a keto weight loss plan is just not restricted to brain-related irritation. It could actually additionally assist people with diabetes as this situation is related to a pro-inflammatory state which will increase the chance of atherosclerosis.

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How Is Chronic Inflammation Diagnosed

Some of the most common signs pointing to a chronic inflammatory response in your body include the following:

  • Frequent infections

Anyone of these things might make you decide to see your doctor. However, youre not likely to hear from your doc that you have chronic inflammation . Its not commonly diagnosed, perhaps because there are no single highly effective ways to test for it.

For many, the first true indication that their immune system is out of balance is a diagnosis of another medical condition that is known to be related to chronic inflammation. Examples of these are diabetes, heart disease, or autoimmune disorders.

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Keto AutoImmune Diet: Burn Fat and Inflammation

First, lets look at sugar consumption: The typical American eats an average of 765 grams of sugar every five days some of it from obvious sources , but much of it from hidden sources in foods that dont seem like they could be dessert . Compare that number to the 45 grams of sugar Americans ate in 1822 over the same 5-day period thats a massive increase.

To look at it in another startling way, every person in the U.S. eats and drinks an average of 130 pounds of added sugar every year, which is an average of 3,550 pounds of sugar over a lifetime. To put that in perspective, that is the equivalent of eating 1.7 million Skittles or an industrial-sized Dumpster full of sugar! Yuck. On top of that, most of us base our diets on foods made from grains: bread, pasta, rice, granola bars, cereals, and crackers, which the body also breaks down into you guessed it sugar.

Putting aside the startling image of an industrial-sized dumpster of sugar, lets look at what all this sugar does to your body. Carbohydrates broken down into glucose results in the most easily accessible energy source. When glucose hits your bloodstream, you release insulin to help carry the glucose around your body and deliver it where it is needed. That doesnt sound so bad, does it? The problem is that most people today eat so much sugar and so many carbohydrates that we end up with blood glucose levels that are dangerously high, since our body doesnt need nearly that much fuel.

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Inflammation Is Actually For Us

Inflammation is actually for us, not against us. It defends us against bacteria and foreign bodies. However, if staying for too long, it becomes life-threatening for us.

Chronic inflammation is the cause of heart disease, diabetes, cancer and co. But, wait a minute, what are the causes of chronic inflammation and how can going keto help?

How Does A Keto Diet Lower Inflammation

Enter our healthier take on the classic keto diet: A plant-rich keto diet is one of the best ways to eat to reduce inflammation. Thats because the keto diet specializes in one really key area: it eliminates two of the most inflammatory foods that we tend to eat, refined sugar and carbohydrates. By getting those out of your diet, youre removing the inflammatory response.

But thats not all a keto approach to eating can do. Along with removing sugar and carbs from your diet comes something called metabolic flexibility. What metabolic flexibility means is that you have the ability to burn both carbs and fats and synthesize your own ketones, an amino acid thats synthesized in the liver from your own body fat.

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Implications Comorbidities And Multiple Benefits

Use of the ketogenic diet has spread internationally in recent years, and therefore it has become a therapy increasingly accessible to many different cultural traditions.58 Across all cultures, patients with chronic pain have among the lowest reported quality-of-life scores of any medical condition, and it has a striking negative impact on economies. In one representative country, chronic pain takes up one-fifth of the entire health care expenditure, whereas in another it is three times as costly as all types of cancer together.59 One strategy which remains unexplored and could yield important insights is to combine a ketogenic diet with a known hypoalgesic pharmacological agent and note additive or synergistic effects, as have been noted for seizure control but only for some drugs.60

Can You Eat Too Much Dairy On A Keto Diet

Can the Keto Diet help me reduce inflammation?

It is very important to monitor your dairy intake when starting out on a keto diet. If you do eat too much dairy, it will slow down the process of getting into ketosis and interrupt the progress you are making on this lifestyle. dairy has a big role in inflammation too.

Inflammation is a process that the body goes through when it comes into contact with an irritant. The body sends inflammatory cells from the blood to the area where there is irritation. One of the inflammatory cells that go up to the irritation is neutrophils, which are white blood cells that contain granules of a substance called myeloperoxidase. Myeloperoxidase is an enzyme that produces hydrogen peroxide, which turns into water and oxygen when it reacts with glutathione to kill off harmful bacteria.

Dairy products have been linked to inflammation in recent years because they contain calcium and vitamin D, which cause excess stomach acid secretion and can lead to inflammation.

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Causes Of Chronic Inflammation

Nothing that happens in the body is simple. Therefore, chronic inflammation cannot be traced back to a single cause . Often there are several factors that form the breeding ground for inflammation.

1. Unhealthy diet

Antioxidants and fibre protect the body cells from harmful substances such as free radicals that attack the cells. Therefore, a diet that contains too little of these substances can promote inflammation in the body.

White sugar and carbohydrates ensure a rapid increase in our blood sugar. An increase in the blood sugar level causes more insulin in order to transport the sugar from the blood into the cells. An increase in insulin then leads to a rapid drop in blood sugar levels. As a result, the rapidly fluctuating blood sugar level produces inflammatory cytokines chemical messengers that cause inflammation.

2. Leaky Gut Syndrome

People with Leaky Gut Syndrome have a permeable intestinal mucosa. Through tears in the intestinal mucosa, bacteria and other harmful substances enter the bloodstream. Since these substances do not belong there, the immune system reacts with an inflammation. The intestinal mucosa can become permeable for various reasons, such as antibiotics, pesticides and excessive consumption of highly processed foods such as ready to eat pizza.

3. Chronic stress

Stress also leads to behaviours that can promote inflammation, such as poor nutrition, alcohol, lack of exercise and poor sleeping habits.

4. Environmental toxins

Food Intolerances Sensitivities And Allergies

Food intolerances, sensitivities, and allergies are often mediated by inflammation. The immune system doesnt recognize a food particle, it attacks, and symptoms soon follow.

Food allergies arent subtle, but food intolerances can be. The trick is to use a food journal so you can correlate specific food with specific symptoms.

Then, simply avoid foods that make you feel lousy. Blood testing is also crucial to determine conditions like celiac, an inflammatory disorder that requires strict abstinence from gluten.

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Ketogenic Diet And Systemic Inflammation

Systemic inflammation is regulated by the production of pro- and anti-inflammatory cytokines. Alterations in the balance of these mediators results in reduction or increase in systemic inflammation . The effects of KD on systemic inflammation are related to three main drivers: insulin reduction, BHB synthesis, glucagon increase . Additionally, since insulin reduction leads to weight loss, all the anti-inflammatory effects of weight loss should be taken into account as well .

Figure 1. Effects of ketogenic diet on systemic inflammation. BHB, beta-hydroxybutyrate IFN-, interferon gamma IL, interleukin NLRP3, NOD-, LRR-, and pyrin domain-containing protein 3 TLR4, toll-like receptor 4 TNF-, tumor necrosis factor-alpha.


Insulin and chronic hyperinsulinemia are associated with an increase of the pro-inflammatory cytokines TNF-, IL-1, IL-1, IL-6, and leptin . Leptin is a unique cytokine due to its adipose-derived origin. Adipose tissue is considered not only as the body’s energy reservoir, but also as an endocrine tissue that can produce proinflammatory cytokines . Furthermore, weight loss is a relevant part of the anti-inflammatory effects of KD and reduction of body’s adipose tissue has an influence on the secretion of hormones such as leptin .



Weight Loss

Less Glutamate More Gaba


Glutamate and GABA are both chemicals that regulate brain activity. Glutamate is excitatory, GABA is relaxative.

Too much inflammation may alter glutamate signaling and cause neurological dysfunction. You see this, for instance, in epilepsy.

In humans, Keto has been shown to increase GABA levelsand it may suppress glutamate too. Because of this, Keto is a promising therapy for epilepsy, Alzheimers, Parkinsons, and other diseases of brain inflammation.

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Is Keto Considered Anti

The ketogenic diet is a popular diet for weight loss and improving health. But is keto considered anti-inflammatory?

The answer to this question depends on the type of inflammation. Some research suggests that inflammation of the joints can be reduced by following a low-carb, high-fat diet. However, some researchers have found that inflammatory markers were not significantly different in people on a ketogenic diet compared to people on a low-fat vegetarian diet. Its possible that the difference in markers has more to do with how long people stay on these diets rather than what type they follow.

Clinical Effects Of The Ketogenic Diet

Insulin reduction and improvement of insulin sensitivity contribute to the clinical effects of KD. Insulin resistance is an impaired response to insulin stimulation of target tissues, primarily liver, muscle and adipose tissue . Insulin signal is conducted through complex intracellular mechanisms regulated by multiple kinase enzymes . One of the most prominent applications of KD is for the purpose of weight loss and a meta-analysis of 60 dietary trials of weight loss suggested insulin reduction as a primum movens of weight loss . Another clinical manifestation of KD related to glucose metabolism and insulin regulation can be observed in patients diagnosed with glucose transporter 1 mutation, which have impaired absorption of glucose from the blood, leading to a reduced supply of nutrients to the brain that manifests as epilepsy. In these patients, KD caused a significant improvement of seizure frequency . Furthermore, KD has been evaluated as part of cancer treatment protocols in brain, colon, breast, and lung tumors. These studies resulted in beneficial effects when used alongside chemotherapy, radiotherapy, or both . Additionally, KD can be used in the setting of Alzheimer’s disease, with an increase in cognitive function , and therapeutic effects have been proposed also for neurologic conditions characterized by substantial motor dysfunction .

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Can Keto Cause Body Aches

Yes, keto can cause body aches. It is because the process of ketosis is an abrupt change in the amount of glucose circulating in your body. Your blood sugar levels will be low so you could experience symptoms like dizziness, fatigue, and headaches.

Keto is a type of diet where the main goal is to limit your carbohydrate intake while increasing fat intake to help with weight loss. It has become popular among people who are trying to lose weight or maintain weight for other health reasons.

Some people find that they experience body aches when they first start keto. Because their bodies are transitioning from using glucose as the energy source to using fat as the energy source for fuel which can impact your mental awareness as well as cognitive function.

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Best Foods To Reduce Inflammation

All vegetables have anti-inflammatory properties, so include veggies like cauliflower, carrots, and cucumbers in your low-carb diet. Herbs and spices, like basil, turmeric, and ginger are anti-inflammatory so use lots of fresh or dried herbs and spices in your cooking.

Though delicious produce like sweet potatoes, corn, bananas, and pineapple are anti-inflammatory, you should limit the amount of high-carb plant foods you consume on a keto diet.

All fruits are anti-inflammatory too, but not all fruits are suitable for a keto diet, at least in large quantities. Same with legumes. They have anti-inflammatory properties and are linked to a reduced risk of heart disease and obesity, but the amount of carbs makes legumes like pinto or black beans unsuitable for a keto diet.

Include a wide variety of plant foods in your keto diet to reduce inflammation, and avoid processed foods, diet drinks, and artificial sweeteners which are known to increase inflammation.

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An Overview Of Inflammation And Nutritional Ketosis

Inflammation is a complex fabric of signals and cellular responses from our immune system that enables our bodies to recognize and respond to infection and injury. Having too weak of an inflammatory response leaves us prone to infection or impaired healing. But having too great of a response, or one that remains over-active for too long, puts us at risk for a form of chronic injury that underlies type 2 diabetes, coronary heart disease, many common cancers, and Alzheimerâs disease.

This balance between too little and too much inflammation is exquisitely delicate, and it is regulated by a number of circumstances including our genetic inheritance, toxins in the environment, and by many components of our diet. One of the first purified drugs designated for human use was an anti-inflammatory compoundâaspirin. Currently, we have a host of different drug classes designed to modulate inflammation, but safely managing their dose and duration of use requires professional vigilance to avoid dangerous side effects.

Health Conditions Linked To Chronic Inflammation

If you wanted to peg a single factor underlying chronic disease, you could make a strong case for chronic inflammation. According to the World Health Organization, inflammatory diseases are the number one threat to the health of our species.

These conditions include:

  • Alzheimers disease

Inflammation may even predict lifespan itself. In one study, low levels of inflammation predicted the healthy aging of centenarians better than telomere length, glucose metabolism, cholesterol levels, and many other biomarkers.

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Fight Inflammation On Keto

A ketogenic diet cuts out the most inflammatory foods there are refined grains and sugar and replaces them with a variety of fatty, anti-inflammatory foods.

The most anti-inflammatory foods you can add to your keto diet include turmeric, ginger, salmon, macadamia, walnuts, healthy fats, and leafy greens.

If youre currently dealing with an inflammation related condition or have a family history of these conditions, start incorporating these foods into your diet today.

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  • 1Medicine and Rheumatology Unit, Istituto di Ricovero e Cura a Carattere Scientifico , Istituto Ortopedico Rizzoli, Bologna, Italy
  • 2Department of Medical and Surgical Sciences, Istituto di Ricovero e Cura a Carattere Scientifico S.Orsola, University of Bologna, Bologna, Italy
  • 3Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • 4Department of Biomedical and Neuromotor Sciences , Alma Mater Studiorum University of Bologna, Bologna, Italy
  • 5Unit of Allergology, Immunology, Rheumatology, Department of Medicine, Università Campus Bio-Medico Di Roma, Rome, Italy

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So What Is Inflammation Anyway

As mentioned earlier, inflammation plays a key role in allowing your body to defend itself from things like illness and infection.

Part of the inflammatory response includes the body boosting the production of immune cells and white blood cells, along with cytokines. All of these help us fight infection.

Some clear indications of short-term inflammation include swelling and redness. Long-term inflammation does not offer any such obvious symptoms, unfortunately, but CAN lead to:

  • and more health conditions

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