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Should Aspirin Be Taken Morning Or Night

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Daily Aspirin – Should You Take It? Cardiologist explains.

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Is Weight Gain A Side Effect Of Meloxicam

Weight gain and loss are uncommon symptoms of taking meloxicam. But fluid retention is, in fact, a common side effect, reported in 0.6% to 4.5% of people taking it. Fluid retention is not treated can lead to cardiovascular problems and further lead to congestive heart failure.

One thing that happens with fluid retention is an involuntary rise in body weight. So, if you see some weight gain, it could affect fluid retention. Visit your doctor immediately.

What Do Studies Say About Dosing Time

The study of how administration time may influence the overall effect of a drug is commonly referred to as ‘chronotherapeutics’ or ‘chronopharmacology’.

Blood pressure medications are very often evaluated in regard to ‘chronotherapeutics’ since elevated blood pressure levels at certain times of the day is more associated with cardiac events compared to other times of the day.

For some drugs, timing doesn’t appear to be important.

For example, one study published in the Journal of Hypertension reported that administration time for Diovan , an ARB blood pressure medication, doesn’t have any effect on 24-hour blood pressure control.

Other studies, however, such as this study published in ‘Hypertension’, showed that evening dosing of Altace , an ACE-Inhibitor like lisinopril, showed significantly better control of blood pressure during the nocturnal hours when compared to morning dosing.

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Heart Attack Risk In The Morning May Be Lowered By Taking An Aspirin At Night

Most heart attacks happen in the morning. For some, a daily low-dose of aspirin may lower this risk. While many take aspirin in the morning, it may be more effective if taken at bedtime.

The American Heart Association recommends that people at high risk of heart attack and heart attack survivors regularly take low-dose aspirin . Aspirin thins the blood and helps prevent clotting.

New research suggests that the best time to take aspirin for heart therapy may be right before going to sleep at night.

“Talk to your doctor about low-dose aspirin to prevent heart attack.”

Tobias Bonten, MD, from the Department of Clinical Epidemiology at Leiden University Medical Center in The Netherlands, and colleagues discovered that a sign of higher heart risk was reduced in patients who took aspirin at night compared to those who took it in the morning.

From a group of 290 patients with previous cardiovascular disease, patients were randomly selected to receive either 100 milligrams of aspirin upon waking or at bedtime over the course of two three-month periods.

At the end of each treatment period, blood pressure was recorded and platelet reactivity was measured.

Platelets are specialized disk-shaped cells in the bloodstream that are involved in the formation of blood clots and play an important role in heart attacks and strokes. Platelets can detect a disruption in the lining of a blood vessel and react to build a wall to stop bleeding.

Aspirin At Bedtime Lowers Blood Pressure

Health Beat: An aspirin a day: Maybe yes, maybe no

May 15 — WEDNESDAY, May 14 — A daily aspirin can control prehypertension, but only if it is taken at bedtime, a Spanish study shows.

An aspirin taken every morning didn’t lower the blood pressure of prehypertensive people, but the evening regimen did, Dr. Ramon C. Hermida reported Wednesday at the American Society of Hypertension annual meeting, in New Orleans.

A previous study by Hermida, who is director of bioengineering and chronobiology at the University of Vigo, showed the same beneficial effect of bedtime aspirin for people with moderately high blood pressure. The new report is the first study to show the drug’s benefit — although only when taken at night — with prehypertension, defined as blood pressure just below the 140/90 level. Prehypertension is a known warning sign of future risk of heart disease, stroke and other cardiovascular problems.

Why aspirin should do its good work for blood pressure at night but not in the daytime is not clear, Hermida said. Research indicates that it can slow the production of hormones and other substances in the body that cause clotting, many of which are produced while the body is at rest.

The three-month study included 244 adults diagnosed with prehypertension. A third of them were advised to follow general rules of hygiene and diet designed to reduce blood pressure, another third were told to take a 100-milligram aspirin tablet every night at bedtime, and the final third were told to take the same aspirin dose on awakening.

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Is It Safe To Take Aspirin Daily

Only in certain cases say, if you have pre-existing heart disease or are at high risk for developing a heart-related problem and only after youve talked to your doctor, says Dr. Nissen.

Most people should not take aspirin because the bleeding risks pretty much counterbalance any benefit on heart attack or stroke, he notes. And the bleeding can be in the gastrointestinal tract or, even more seriously, bleeding can occur into the brain.

The new U.S. Preventive Services Task Force guidance also recommends people between ages 40 and 59 with no previous heart issues should talk to their doctor about whether taking a daily aspirin is right for them.

However, Dr. Nissen stresses that age isnt the best gauge for determining aspirin use.

Instead, its much more important to take into account whether youve had a heart attack or stroke in the past, or if you have pre-existing heart issues, such as coronary artery disease.

Baby aspirin is not a benign intervention, Dr. Nissen says. There has been evidence for many years that for patients who have never had a cardiovascular event, taking daily aspirin poses as many risks as benefits.

What Is The Best Time Of Day To Take 81 Mg Low Dose Aspirin Used For Heart Problems

Question posted by laniebear1 on 17 Aug 2014


I would take it after breakfast, then I’d be taking it with food in my stomach.


Studies show that the best time to take low dose aspirin is at bedtime. It reduces the chance of morning clots. This information comes from WebMD, the Mayo Clinic and the American Heart Association.

“8:31 AM – November 21, 2013Daily aspirin users may be better protected against heart disease or stroke if they take the blood-thinning pills before turning in at night, according to new research presented at the American Heart Association’s annual meeting in Dallas this week.”

Doug Foley

Not being able to make it through the night without getting up to urinate – when drinking before bedtime – I would take 81 mg of aspirin without water before retiring. The aspirin are quite small and easy to swallow, or so I thought, but apparently the aspirins were not going down. Over time the aspirin seems to have done damage in the throat area resulting in audible gurgling sounds that are loud enough for my dinner companions to hear. I now take aspirin first thing in the morning, with water, just before breakfast. Over time the frequency and loudness of these embarrassing sounds are diminishing.

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Who Should Consider Taking Prenatal Aspirin

To prevent all variations of preeclampsia including HELLP syndrome, according to the U.S. Preventive Services Task Force guidelines, women with one or more high-risk factors should take low-dose aspirin. Women with several moderate-risk factors may also benefit from low-dose aspirin.

Risk Level
  • Type 1 or 2 diabetes
  • Renal disease
  • Autoimmune disease

Recommend low-dose aspirin if the patient has one or more of these high-risk factors

  • Nulliparity
  • Family history of preeclampsia
  • Sociodemographic characteristics
  • Age 35 years
  • Personal history factors

Recommend low-dose aspirin if the patient has two or more of these moderate risk factors consider low-dose aspirin if the patient has at least one of these moderate risk factors


Do not recommend low-dose aspirin

Urgent Advice: Phone 999 Or Go To A& e If:

Aspirin: To Take Or Not To Take

You are taking aspirin and have symptoms like:

  • hives a raised, itchy rash
  • tinnitus hearing sounds that come from inside your body
  • breathing difficulties or an asthma attack
  • an allergic reaction this can cause breathing problems, swelling of the mouth, lips or throat, and a sudden rash
  • severe headaches

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Side Effects Of Aspirin

The most serious side effect of taking aspirin is an increased risk of bleeding. Studies have found a higher risk for hemorrhage from stroke or in the upper gastrointestinal tract.

Another study suggested that healthy older adults taking daily aspirin were at increased risk for death from any cause, including cancer.

In 2018, researchers of a five-year study involving nearly 20,000 healthy older adults over age 70 who either took 100 mg of aspirin each day or a placebo pill.

The result? They found that the group who took aspirin had a higher bleeding rate without any cardiovascular benefits.

This was a high-quality study conducted as a randomized, double-blind, placebo-controlled trial, a method that keeps researchers themselves unaware about which patients have the placebo.

Are There Any Benefits

People who have been diagnosed with heart disease should still take a low dose of daily aspirin, defined as a dose thats typically 81 milligrams.

Thats because aspirin has anti-platelet, anti-clotting effects that can help keep heart patients arteries open, which is the reason it can benefit people who already have heart disease.

Platelets play a key role in clotting, says Dr. Nissen. And aspirin is a very potent anti-platelet agent because it permanently inhibits the ability of platelets to stick together via a certain mechanism of stickiness. Thats why its useful in secondary prevention, where the risks are very, very high.

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Aspirin At Bedtime Vs Aspirin In The Morning: Which Produces Greater Cardiovascular Benefits

Although there appears to be no difference in blood pressure reduction in patients who take aspirin at bedtime compared to those who take it when they awake in the morning, bedtime aspirin may be associated with reduced morning platelet reactivity.

Aspirin is the most commonly used medication for cardiovascular disease prevention, with millions of patients using it every day. Although previous studies have indicated that patients with hypertension who take aspirin at bedtime experience slightly better blood pressure control compared to patients who take aspirin in the morning, similar comparison studies in patients with cardiovascular disease have not been performed.

Because studies have shown that platelet reactivity and cardiovascular disease incidence is highest during morning hours, researchers have proposed that taking aspirin at bedtime may attenuate morning platelet reactivity.

To test this hypothesis, Tobias Bonten, MD, cardiologist with Leiden University Medical Center in Leiden, Netherlands, looked at the effect of aspirin intake at bedtime compared with intake on awakening on 24-hour ambulatory blood pressure measurement and morning platelet reactivity in patients using aspirin for CVD prevention.

He reported the study results from Does Aspirin Intake at Bedtime Decrease Blood Pressure and Morning Peak of Platelet Reactivity?: A Randomized Cross-over Trial during a poster session at the 2013 American Heart Association Scientific Sessions.

What Are The Worst Side Effects Of Meloxicam

Aspirin Guidelines: Some Should Take It to Prevent Heart Attack

Some severe side effects include heart attack, chest pain, stroke, stomach, and intestinal problems, liver damage, increased blood pressure, water retention, skin problems, or kidney damage like dark urine.

Its essential to be aware of any symptoms which might indicate youre suffering from severe side effects by taking this medication. Immediately refer to your healthcare provider to get your condition treated right away.

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Cyclicity Of Cardiovascular Complications

Myocardial infarctions show weekly variability, with the peak on Monday, and seasonal intensification in the winter season . The results of clinical observations conducted many years ago showed that the number of acute coronary events, strokes, sudden cardiac death, symptoms of rupturing dissecting aortic aneurysms increases in the morning hours . This was confirmed by an analysis of the incidence of acute coronary events, which revealed a circadian rhythm with the peak in the morning hours, between 6:00 and 10:00 . Studies analyzing the occurrence of sudden death caused by arrhythmia and heart rate variability also revealed an increase in the frequency of cardiac arrests in the morning. The circadian rhythm was more pronounced in the elderly and non-hospitalized patients. Circadian heart rate variability is one of the determinants of the risk of sudden death .

Individuals with a normal pressure drop at night are referred to as dippers. Disorders of the circadian blood pressure profile may consist in insufficient pressure drops at night , higher pressure values at night than during the day , or pressure drops at night that are too pronounced . Non-dippers account for 2040% of patients with hypertension. This phenomenon is particularly common in patients with secondary hypertension as well as in elderly and male individuals .

Should You Take Daily Aspirin

It depends. Basically, it all boils down to whether youre at high risk for having a heart-related problem factors might include high blood pressure, high cholesterol, being a smoker or having diabetes and your previous medical history.

If youve had a heart attack, or a stent, or bypass surgery, or some other manifestation of coronary heart disease, then aspirin is recommended in order to prevent a recurrent event, says Dr. Nissen.

If you havent had a cardiovascular event, but are taking daily aspirin anyway, should you stop taking it? It also depends. In general, I tell my patients to stop, says Dr. Nissen. But different physicians may have a different perspective. They might argue that somebody whos taken it for 10 years and has a very low risk of a gastrointestinal or cerebral bleed, maybe its not a bad idea to keep taking it.

What you definitely shouldnt do is just stop or start taking aspirin without consulting your doctor first. Its always good idea to talk to your doctor, says Dr. Nissen. Nothing in medicine is ever black and white, and individualizing care is always a good idea. Talk to your doctor and try to work it out together. We call that shared decision-making. Its always the right thing to do.

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Consider The Side Effects

One of the most important considerations when picking a time to take your daily dose of lisinopril are the potential side effects.

Some of the most common side effects of lisinopril include:

If you have taken blood pressure medication before, and experienced any of these side effects, taking your lisinopril at bedtime versus in the morning may be a better option. It won’t much matter if lisinopril makes you tired if you are simply going to bed!

Lisinopril Dosing Time Studies

Should You Take Aspirin To Prevent Heart Disease?

Where lisinopril is concerned, there are a few studies that suggest that nighttime dosing may be preferred over morning dosing to better control night-time and early morning blood pressure.

One such study, published in European Review for Medical and Pharmaceutical Sciences, concluded the following:


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An Aspirin Before Bed May Reduce Morning Heart Attacks

  • New study found people who took aspirin before bed had less platelet activity
  • This could mean an aspirin at bedtime would lead to fewer morning heart attacks
  • More research is needed to see if the correlation is true

Here’s some news that may be useful to millions of people who take a low-dose aspirin for their heart health: Taking the aspirin before bed may reduce the chance of having a heart attack or stroke in the morning, a new study suggests.

The American Heart Association recommends that people at high risk of having a heart attack should take a daily low dose of aspirin, if told to by their health care provider, and that heart attack survivors regularly take low-dose aspirin.

Aspirin keeps platelets from forming clots, which can cause heart attack and strokes, says cardiologist Sidney Smith Jr., a professor at the University of North Carolina School of Medicine and a spokesman for the heart association. “Heart attacks are more likely to occur in the morning, so anything that would reduce platelet activity during the morning hours could be beneficial.”

Researchers in the Netherlands studied 290 patients with heart disease who were already taking aspirin. They had participants take 100 milligrams of aspirin either after they woke up in the morning or at bedtime during two three-month periods. At the end of each period, they measured participants’ blood pressure and platelet activity.

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